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In addition, LDHB KD plus Erastin or RSL3 synergistically inhibited A549, H838, and H460 the viability, which could be rescued by FER1, partially by the necrosis inhibitor (NEC) due to the shared features of the two processes [44], but not by inhibitors of autophagy (HCQ) or apoptosis (ZVF) ( Supplementary Figure 4b, c, d )

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Abdelrazik H, Sharma R, Mahfouz R, Agarwal A

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If true, such a scenario would pose a formidable challenge to the research community, because distinguishing a physiological form of an otherwise normal endogenous brain protein from a pathologically misfolded/aggregated conformer is not trivial

DOI: 10.7860/JCDR/2017/23846.9281 7